When it comes to defensive-handgun cartridges and ammo, I have preferences and biases. But, I also acknowledge when it comes to stopping a bad guy with a handgun there are no absolutes. You cannot predict with any certainty how fast incapacitation will occur. Sure, central nervous system and spinal hits should be immediate and sometimes a hit anywhere is enough to change a felon’s mind. The problem is, there’s no guarantee of getting the former, and the latter might not incapacitate.